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Januvia Sitagliptin Phosphate: Side Effects, Uses, Dosage, Interactions, Warnings

Januvia can still be used if you have kidney problems, although usually at a lower dose. Talk to your doctor if you’re worried about any Januvia side effects. For breastfeeding, there’s no data on whether or not Januvia can pass into breast milk in humans. This was found to be the case in animal studies however, so there is a possibility Januvia could pass into your breast milk. Talk to your doctor about taking Januvia if you are breastfeeding or plan to breastfeed, or if you express milk in another way, such as with a breast pump. It’s important to always take your medication exactly as your doctor prescribed it.

  1. But according to a review of clinical studies, it’s not clear whether chromium is effective and safe for treating high blood sugar caused by type 2 diabetes.
  2. Your doctor or pharmacist can tell you more about these interactions and any others that may occur with use of Januvia.
  3. Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine.

Incretins help control your body’s blood sugar levels. When you eat a meal, your digestive tract releases incretins. They affect your pancreas, stimulating it to make and release insulin. With real-world medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials.

Like Januvia, glipizide is a diabetes drug that stimulates the pancreas to release insulin. (Insulin helps lower blood sugar levels.) It belongs to the same group of diabetes drugs as glyburide (Glynase) and glimepiride (Amaryl). Januvia blocks a certain protein in your body that inactivates incretin hormones. These hormones help control your blood sugar levels by affecting your pancreas and stimulating it to make and release insulin. By blocking the protein, more active incretin hormones are available to help control your blood sugar levels.

Januvia (sitagliptin) is an oral types 2 diabetes medicine that can help you lower your blood sugar and reach your target goals. It typically does not cause low blood sugar or weight gain when used alone our salvia guide the salvia experience, benefits, dosage and more without other diabetes medications. The most common side effects caused by Januvia include headaches, a stuffy or runny nose, a sore throat, and an increase in upper respiratory tract infections.

Patient Information for Januvia

This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval. Normally, incretin hormones are rapidly deactivated by an enzyme called dipeptidyl peptidase 4 (DPP-4). However, Januvia is in a class of drugs known as dipeptidyl peptidase 4 (DPP-4) inhibitors, which work by blocking the deactivation of incretin hormones.

In addition to helping prevent pregnancy, the hormones in birth control pills can increase the amount of sugar in your blood. With this higher level of sugar in your blood, Januvia may not work as well. Below is a list of medications that can interact with Januvia.

Selected Risk Information About JANUVIA® (sitagliptin)

No adverse effect on fertility was observed at 125 mg/kg (approximately 12 times human exposure at the MRHD of 100 mg/day based on AUC comparisons). At higher doses, nondose-related increased resorptions in females were observed (approximately 25 and 100 times human exposure at the MRHD based on AUC comparison). Through Week 54, the overall incidence of hypoglycemia was 3.9% in patients given add-on JANUVIA and 1.0% in patients given add-on placebo.

Do Januvia’s side effects vary by strength: 25 mg, 50 mg, and 100 mg?

To treat pancreatitis, your doctor will give you fluids through an intravenous (IV) injection. If you have pancreatitis, your doctor may have you stop taking Januvia. But do not stop taking the drug without first talking with your doctor. To protect your privacy, please change your password at this time.

Although Januvia by itself usually does not cause low blood sugar (hypoglycemia), low blood sugar may occur if Januvia is prescribed with other anti-diabetic medications. Other symptoms of low blood sugar, such as dizziness, hunger, or sweating, are unaffected by these drugs. If you’ve had heart failure in the past, taking Januvia may increase your risk of developing the condition again.

But sitagliptin, Januvia’s active ingredient, is used in other combination drugs that may cause yeast infections as a side effect. For example, people taking Steglujan (ertugliflozin/sitagliptin) have reported yeast infections as a side effect. Both Steglujan meth withdrawal: symptoms duration coping tips and more and Januvia are brand-name drugs used to treat type 2 diabetes. In one study, some people took 100 mg of Januvia each day, while others took 200 mg. The study found that the 200-mg dose wasn’t more effective for treating type 2 diabetes than the 100-mg dose.

But more evidence is needed to confirm this recommendation. All the drugs mentioned here treat type 2 diabetes, but they don’t treat type 1 diabetes. But do not stop taking Januvia without first talking with your doctor. Your doctor may have you stop taking Januvia if you have severe and disabling joint pain. If you have joint pain after starting Januvia, talk with your doctor right away.

As the level of sugar in your blood increases, the level decreases in your cells and organs. So your pancreas tries to make more insulin to help manage your blood sugar. But in most cases, your body won’t be able to make enough insulin. Heart failure wasn’t reported as a side effect in any clinical study of Januvia. If you have symptoms of hypoglycemia (see the “Serious side effects” section above), tell your doctor.

Many patients first diagnosed with type 2 diabetes start on an oral medication known as metformin. It increases your cells ability to utilize glucose (blood sugar) by improving how your insulin works and decreases liver glucose production and absorption. It’s used together with diet and exercise to help manage blood sugar levels in adults with type 2 diabetes. With this condition, your blood sugar levels are too high.

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